Brachytherapy, also called internal radiation therapy, places radioactive sources inside the cancer, on a temporary or permanent basis, to kill the cancer cells from within.
For the temporary form, radioactive material is placed inside a catheter during treatment time and then withdrawn. Temporary brachytherapy can be applied at a high-dose rate (HDR) or low-dose rate (LDR). For permanent brachytherapy, also known as seed implantation, the radioactive seeds are placed in or near the tumor and left there permanently.
The radioactivity level decreases with time, and eventually diminishes to nothing after a few months. Brachytherapy allows for a higher total dosage of radiation within a smaller area. Unlike focal treatments such as IRE, brachytherapy is not completed within one session, but usually several sessions are required, and in case of permanent brachytherapy, the treatment will last for several months.
Potency preservation rates
Numbers for Brachytherapy consider high dose rate (HDR) brachytherapy as monotherapy in the treatment of localized prostate cancer, whereas we have compared them to total potency preservation outcome of IRE of all treated patients, which include high grade, non-organ confined PCa as well.
Citation for Brachytherapy numbers: Tselis, N., et al. "High Dose Rate Brachytherapy as Monotherapy for Localized Prostate Cancer: Review of the Current Status." Clinical Oncology (2017).